Understanding the causes of youth-onset Type 2 diabetes
Official title: Identifying Metabolic and Psychosocial Antecedents and Characteristics of youth-onset Type 2 diabetes (IMPACT DM)
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11051192 · Data updated 2026-11-12
This study is looking at how different physical and emotional factors can lead to Type 2 diabetes in young people, especially those from minority backgrounds, so we can find ways to help those at risk before it happens.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | February 23, 2023 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $569,717 |
| NIH project number | 5U01DK135007-03 |
| Project ID | NIH-11051192 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are youth aged 0-11 years, particularly those exhibiting signs of abdominal obesity or belonging to minority racial and ethnic groups.
✕Less likely to help
Patients who are older than 11 years or do not exhibit risk factors for youth-onset Type 2 diabetes may not benefit from this research.
What this research studies
This research aims to identify the metabolic and psychosocial factors that contribute to the development of youth-onset Type 2 diabetes (YOT2D). By focusing on young individuals, particularly those from minority backgrounds, the study will analyze various physiological and psychological influences, including puberty and childhood experiences. Participants will undergo detailed assessments to gather data on their physical health, metabolic function, and psychosocial environment. The ultimate goal is to create a prediction model that can identify at-risk youth, enabling early intervention and prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for youth-onset Type 2 diabetes, potentially reducing long-term health complications.
How similar studies have gone: Previous research has shown success in identifying risk factors for adult-onset diabetes, but this specific focus on youth-onset Type 2 diabetes is relatively novel.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Tryggestad, Jeanie Beatrice — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Tryggestad, Jeanie Beatrice
Related research
Other NIH-funded projects on the same topics.
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Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
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-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
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-
Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
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This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.