Understanding the causes of white matter changes in the brain related to Alzheimer's disease
Pathological mechanisms of white matter hyperintensities
This study is looking at how certain changes in the brain, called white matter hyperintensities, affect older adults who might be at risk for Alzheimer's disease, with the goal of finding ways to help prevent memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10876909 on NIH RePORTER |
What this research studies
This research investigates the underlying mechanisms of white matter hyperintensities (WMHs) in the brains of older adults who are at risk for Alzheimer's disease. Using advanced imaging techniques, the study aims to identify how factors like axon and myelin loss, fluid retention, and blood-brain barrier dysfunction contribute to cognitive decline. By examining different types of WMHs, the research seeks to differentiate between vascular and neurodegenerative causes, which could lead to targeted interventions. The findings may help develop strategies to prevent the progression of WMHs and associated cognitive impairment.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who show signs of cognitive decline and are at risk for Alzheimer's disease.
Not a fit: Patients who are not at risk for Alzheimer's disease or do not exhibit cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent cognitive decline in individuals at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in using advanced imaging techniques to study brain changes, indicating that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Rane Levendovszky, Swati — University of Washington
- Study coordinator: Rane Levendovszky, Swati
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.