Understanding the causes of VEXAS Syndrome
Official title: Elucidation of the mechanism of disease of VEXAS Syndrome
Funded at New York University School of Medicine · NIH-11020936 · Data updated 2026-11-12
This study is looking into VEXAS Syndrome, a condition that causes inflammation and blood problems, especially in older men, to better understand how changes in a specific gene might lead to the disease and help find new treatment options for those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30HL170731-02 |
| Project ID | NIH-11020936 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older men, particularly those over 50, who have been diagnosed with VEXAS Syndrome or exhibit symptoms related to it.
✕Less likely to help
Patients who are not male or those under the age of 50 may not benefit from this research.
What this research studies
This research investigates VEXAS Syndrome, a newly identified disease that affects the bone marrow and causes inflammation and blood disorders, particularly in older men. The study focuses on the UBA1 gene, which plays a crucial role in regulating protein functions in the body. By examining how mutations in this gene lead to the disease, researchers aim to uncover new insights into its mechanisms and potential treatments. Patients with VEXAS Syndrome often experience severe symptoms and currently have limited treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from VEXAS Syndrome.
How similar studies have gone: While VEXAS Syndrome is a relatively new condition, previous research on similar genetic and inflammatory diseases has shown promise in understanding their mechanisms and developing targeted therapies.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Magaziner, Samuel James — New York University School of Medicine
- Study coordinator: Magaziner, Samuel James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.