Understanding the causes of type 2 diabetes in children and adolescents
Official title: Cincinnati Children's Clinical Center for Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11051124 · Data updated 2026-11-12
This study is looking for kids and teens who might be at risk for type 2 diabetes to help understand what causes the condition, so we can find better ways to prevent it in the future.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 10, 2023 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $751,761 |
| NIH project number | 5U01DK134976-03 |
| Project ID | NIH-11051124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children and adolescents who are at risk for developing type 2 diabetes, particularly those with obesity or a family history of diabetes.
✕Less likely to help
Patients who are not at risk for type 2 diabetes or those who have already been diagnosed with the condition may not benefit from this research.
What this research studies
This research investigates the underlying causes of youth-onset type 2 diabetes (T2D) by recruiting a cohort of children and adolescents who are at risk for developing this condition. Participants will undergo detailed assessments of their pancreatic function, insulin sensitivity, and various metabolic factors, alongside evaluations of their genetics and psychosocial behaviors. The goal is to identify how these factors contribute to the progression of T2D, ultimately aiming to improve prevention strategies for this aggressive disease.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for youth-onset type 2 diabetes, improving health outcomes for affected children and adolescents.
How similar studies have gone: Previous research has shown promise in understanding diabetes through similar observational cohort studies, indicating that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Shah, Amy Sanghavi — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Shah, Amy Sanghavi
Related research
Other NIH-funded projects on the same topics.
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Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.
-
Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
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Personalized use of newer diabetes medicines for Type 2 diabetes
Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.
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Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.