Understanding the causes of thoracic aorta diseases using computer models
Official title: ELUCIDATING MECHANISMS OF THORACIC AORTOPATHY VIA COMPUTATIONAL MODELING
Funded at Yale University · NIH-10977688 · Data updated 2026-11-12
This study is looking at how certain changes in the body can lead to serious heart problems, like aortic aneurysms and dissections, especially in people with high blood pressure, and it aims to find ways to better understand and treat these conditions by focusing on specific immune cells called macrophages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 10, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $705,944 |
| NIH project number | 1R01HL169147-01A1 |
| Project ID | NIH-10977688 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with thoracic aortopathy, particularly those with a genetic predisposition or hypertension.
✕Less likely to help
Patients without thoracic aortopathy or those not experiencing hypertension may not benefit from this research.
What this research studies
This research investigates thoracic aortopathy, which includes conditions like aneurysms and dissections that can lead to serious health issues. By utilizing computational modeling, the study aims to explore how changes in cell signaling and gene expression contribute to these conditions, particularly in patients with hypertension. The research will focus on understanding the roles of macrophages and how they might influence the progression of aortic diseases. This approach seeks to identify potential protective mechanisms and improve treatment strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of thoracic aorta diseases, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding aortic diseases through genetic and biomechanical studies, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Humphrey, Jay D. — Yale University
- Study coordinator: Humphrey, Jay D.
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.