Understanding the causes of thoracic aorta diseases using computer models
ELUCIDATING MECHANISMS OF THORACIC AORTOPATHY VIA COMPUTATIONAL MODELING
This study is looking at how certain changes in the body can lead to serious heart problems, like aortic aneurysms and dissections, especially in people with high blood pressure, and it aims to find ways to better understand and treat these conditions by focusing on specific immune cells called macrophages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10977688 on NIH RePORTER |
What this research studies
This research investigates thoracic aortopathy, which includes conditions like aneurysms and dissections that can lead to serious health issues. By utilizing computational modeling, the study aims to explore how changes in cell signaling and gene expression contribute to these conditions, particularly in patients with hypertension. The research will focus on understanding the roles of macrophages and how they might influence the progression of aortic diseases. This approach seeks to identify potential protective mechanisms and improve treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with thoracic aortopathy, particularly those with a genetic predisposition or hypertension.
Not a fit: Patients without thoracic aortopathy or those not experiencing hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of thoracic aorta diseases, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding aortic diseases through genetic and biomechanical studies, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Humphrey, Jay D. — Yale University
- Study coordinator: Humphrey, Jay D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.