Understanding the causes of symptom clusters in heart failure
Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF)
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10768648
This study is looking at how different symptoms of heart failure come together and impact the lives of adults with the condition, especially after they've been in the hospital, to find better ways to help manage those symptoms and improve their overall well-being.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10768648 on ClinicalTrials.gov |
What this research studies
This research investigates the complex symptoms experienced by adults with heart failure, particularly focusing on how these symptoms cluster together and affect patients' quality of life. By analyzing a multi-biomarker panel and the physical frailty phenotype, the study aims to uncover the biological and physiological mechanisms behind these symptoms, especially during the critical period following hospitalization. The goal is to improve symptom management and outcomes for heart failure patients by identifying patterns that may not be evident through traditional hemodynamic measures.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with heart failure, particularly those experiencing significant symptom burden.
Not a fit: Patients with heart failure who are asymptomatic or have stable symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for heart failure symptoms, enhancing patients' quality of life.
How similar studies have performed: Previous research has indicated that understanding symptom clusters in heart failure can lead to improved management strategies, suggesting that this approach has potential for success.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENFELD, QUIN ELEANOR — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: DENFELD, QUIN ELEANOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.