Understanding the causes of stroke and how patients respond to treatments
Official title: Transcriptomics of Stroke Thrombus to Determine Stroke Etiology and Response to Revascularization Therapies
Funded at Yale University · NIH-11054914 · Data updated 2026-11-12
This study is looking at the genetic and biological reasons behind ischemic strokes caused by blocked blood vessels, and it needs patients to help by providing tissue and blood samples so we can better understand these strokes and improve treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $230,560 |
| NIH project number | 1K23NS136843-01A1 |
| Project ID | NIH-11054914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke due to large vessel occlusion.
✕Less likely to help
Patients who have not experienced a stroke or have strokes caused by factors unrelated to thrombi may not benefit from this research.
What this research studies
This research investigates the genetic and biological factors involved in ischemic strokes caused by large vessel occlusion. By analyzing tissue and blood samples from stroke patients, the study aims to identify the underlying causes of stroke thrombi and how they respond to revascularization therapies. The research will utilize advanced computational biology techniques to enhance our understanding of stroke etiology and improve treatment outcomes. Patients may be involved in providing samples and data that will contribute to this important work.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment strategies for stroke patients.
How similar studies have gone: Previous research has shown promise in using transcriptomic analysis to understand stroke mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Giles, James Anthony — Yale University
- Study coordinator: Giles, James Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.