Understanding the causes of severe nearsightedness and its effects on the eyes
Official title: Elucidation of the Molecular Mechanisms Driving Genetically-Induced High Myopia
Funded at Johns Hopkins University · NIH-11030850 · Data updated 2026-11-12
This study is looking into how certain genes can cause severe nearsightedness and related eye problems, hoping to find new ways to help manage these conditions better for people who struggle with high myopia.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $237,523 |
| NIH project number | 5K08EY033852-04 |
| Project ID | NIH-11030850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetically-induced high myopia or inherited retinal dystrophies.
✕Less likely to help
Patients with myopia not linked to genetic factors or those without retinal complications may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind genetically-induced high myopia, focusing on how increased TGFβ signaling contributes to the progression of this condition and related retinal diseases. By studying specific mouse models, the research aims to identify the role of certain proteins in myopia development and retinal degeneration. The approach includes examining changes in eye structure and signaling pathways that may lead to new therapeutic targets for treatment. Patients may benefit from insights that could lead to improved management of high myopia and associated eye conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or slow the progression of high myopia and its complications.
How similar studies have gone: Previous research has shown promising results in understanding the molecular pathways involved in myopia, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Doyle, Jefferson James — Johns Hopkins University
- Study coordinator: Doyle, Jefferson James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.