Understanding the causes of Primary Biliary Cholangitis
Official title: Pathogenesis of Primary Biliary Cholangitis
Funded at Mayo Clinic Rochester · NIH-10747958 · Data updated 2026-11-12
This study is looking into how Primary Biliary Cholangitis (PBC) works in the body, focusing on the immune system and environmental influences, to help create better, personalized treatments for people living with this liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | December 21, 2020 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $619,745 |
| NIH project number | 5R01DK126691-04 |
| Project ID | NIH-10747958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Primary Biliary Cholangitis, particularly those experiencing symptoms related to the disease.
✕Less likely to help
Patients with other liver diseases or autoimmune conditions unrelated to Primary Biliary Cholangitis may not benefit from this research.
What this research studies
This research investigates the underlying mechanisms of Primary Biliary Cholangitis (PBC), a rare autoimmune liver disease, using a multi-omics approach. By analyzing various biological data, the study aims to identify the immune system's role and environmental factors that contribute to the disease. The research employs advanced machine learning techniques to uncover complex biological pathways and develop tailored therapies for patients. This comprehensive understanding could lead to significant advancements in personalized care for those affected by PBC.
Why it matters
Potential benefit: If successful, this research could lead to new, effective therapies and improved personalized care for patients with Primary Biliary Cholangitis.
How similar studies have gone: Previous research utilizing multi-omics approaches has shown promise in understanding autoimmune diseases, suggesting potential success for this novel investigation.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Lazaridis, Konstantinos N — Mayo Clinic Rochester
- Study coordinator: Lazaridis, Konstantinos N
Related research
Other NIH-funded projects on the same topics.
-
Role of MAIT Cells in Primary Biliary Cholangitis (PBC)
This grant investigates how MAIT immune cells contribute to the autoimmune liver disease PBC and what that means for future therapies.
-
P2RY8 in liver blood vessel cells and B cells in autoimmune liver disease
This grant explores how a liver blood-vessel cell signal (P2RY8) might influence B cells and antibodies in primary biliary cholangitis, a liver autoimmune disease.
-
Seladelpar and Cilofexor in Primary Biliary Cholangitis (PBC)
This study tests whether combining seladelpar with cilofexor helps people with primary biliary cholangitis more than seladelpar alone or placebo.
-
Austrian PBC Registry
This registry follows adults with primary biliary cholangitis in Austrian centers to see how the disease develops over time and how biomarkers relate to complications and symptoms.
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Biochemical response and health outcomes in people with primary biliary cholangitis
We will follow adults with primary biliary cholangitis who are taking ursodeoxycholic acid (UDCA) to see if their alkaline phosphatase levels after treatment predict how long they stay free of complications.
-
Saroglitazar Magnesium for PBC with incomplete UDCA response or intolerance
This study tests whether Saroglitazar Magnesium can help people with primary biliary cholangitis who still have high alkaline phosphatase despite UDCA or cannot take UDCA.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.