Understanding the causes of Primary Biliary Cholangitis
Pathogenesis of Primary Biliary Cholangitis
This study is looking into how Primary Biliary Cholangitis (PBC) works in the body, focusing on the immune system and environmental influences, to help create better, personalized treatments for people living with this liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10747958 on NIH RePORTER |
What this research studies
This research investigates the underlying mechanisms of Primary Biliary Cholangitis (PBC), a rare autoimmune liver disease, using a multi-omics approach. By analyzing various biological data, the study aims to identify the immune system's role and environmental factors that contribute to the disease. The research employs advanced machine learning techniques to uncover complex biological pathways and develop tailored therapies for patients. This comprehensive understanding could lead to significant advancements in personalized care for those affected by PBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Primary Biliary Cholangitis, particularly those experiencing symptoms related to the disease.
Not a fit: Patients with other liver diseases or autoimmune conditions unrelated to Primary Biliary Cholangitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective therapies and improved personalized care for patients with Primary Biliary Cholangitis.
How similar studies have performed: Previous research utilizing multi-omics approaches has shown promise in understanding autoimmune diseases, suggesting potential success for this novel investigation.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lazaridis, Konstantinos N — Mayo Clinic Rochester
- Study coordinator: Lazaridis, Konstantinos N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.