Understanding the causes of pelvic and abdominal pain
Official title: Molecular and cellular mechanisms of visceral pain and cross-organ sensitization
Funded at Icahn School of Medicine at Mount Sinai · NIH-10997075 · Data updated 2026-11-12
This study is looking into how pain from bladder issues, like interstitial cystitis, can also affect the gut and cause more pain, with the hope of finding better ways to diagnose and treat these conditions for people who suffer from them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 20, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $730,883 |
| NIH project number | 1R01DK141106-01 |
| Project ID | NIH-10997075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with interstitial cystitis/bladder pain syndrome or irritable bowel syndrome.
✕Less likely to help
Patients with pain conditions unrelated to bladder or gastrointestinal issues may not receive benefit from this research.
What this research studies
This research investigates the underlying molecular and cellular mechanisms that contribute to visceral pain, particularly focusing on conditions like interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS). By examining how bladder inflammation can affect the colon and lead to increased pain sensitivity, the study aims to uncover the connections between these two disorders. The approach includes using advanced techniques to manipulate specific nerve cells and observe their responses, which could lead to new insights into pain management. Patients may benefit from improved diagnostics and treatment options as a result of this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from chronic pelvic and abdominal pain.
How similar studies have gone: Previous studies have shown promising results in understanding the mechanisms of visceral pain, suggesting that this research could build on established findings.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Kim, Brian — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kim, Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.