Understanding the causes of pain in neuromas
Project 2: The cell types and states of painful neuromas
['FUNDING_OTHER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10928099
This study is looking at nerve tissue samples to better understand what causes pain in neuromas, with the hope of finding new, personalized treatments for people who experience this type of pain.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10928099 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a biobank of human neuroma and intact nerve tissues to analyze the biological mechanisms behind pain in neuromas. By conducting detailed transcriptomic, proteomic, and histological analyses, the research aims to identify the specific cellular and molecular features associated with painful neuromas. This comprehensive approach will help uncover the role of immune and glial cells in neuropathic pain, potentially leading to new treatment strategies tailored to individual patient profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing neuropathic pain related to neuromas.
Not a fit: Patients without painful neuromas or those with other unrelated pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for patients suffering from neuropathic pain due to painful neuromas.
How similar studies have performed: Previous research has shown promise in understanding neuropathic pain mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOOLF, CLIFFORD J — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: WOOLF, CLIFFORD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.