Understanding the causes of pain in endometriosis
Peripheral and central mechanisms of endometriosis pain
This study is looking at why women with endometriosis experience pain and aims to find out how different factors, like hormones, affect that pain, so if you're a woman dealing with pelvic pain, whether or not you have endometriosis, you can help us learn more by sharing your experiences before and after a small surgery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11136788 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind pain experienced by women with endometriosis, a condition where tissue similar to the lining of the uterus grows outside of it. The study will analyze both central and peripheral factors that may contribute to pain, including hormonal influences and pain modulation responses. Women with pelvic pain, whether or not they have endometriosis, will undergo assessments before and after laparoscopic surgery to evaluate changes in their pain levels. The goal is to identify specific biological markers that could predict pain severity and response to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult women experiencing chronic pelvic pain, particularly those diagnosed with endometriosis or undergoing surgery for its treatment.
Not a fit: Patients who do not experience pelvic pain or have conditions unrelated to endometriosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies for women suffering from endometriosis.
How similar studies have performed: Previous research has shown promise in understanding pain mechanisms in endometriosis, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Nahman-Averbuch, Hadas — Washington University
- Study coordinator: Nahman-Averbuch, Hadas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.