Understanding the causes of nonalcoholic steatohepatitis (NASH)
Pathobiology of Nonalcoholic Steatohepatitis
This study is looking at how certain harmful fats in the liver can cause inflammation and make nonalcoholic steatohepatitis (NASH) worse, with the goal of finding new ways to help people with this liver condition feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10886700 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular mechanisms behind nonalcoholic steatohepatitis (NASH), a serious liver condition. It focuses on how toxic lipids in liver cells lead to inflammation and immune responses that worsen the disease. By studying these processes, the researchers aim to identify potential therapeutic strategies to reverse the damage caused by NASH. The study utilizes animal models to explore the role of specific proteins and immune cells in the progression of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with nonalcoholic steatohepatitis or those at risk of developing this condition.
Not a fit: Patients with alcoholic liver disease or other liver conditions unrelated to NASH may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from NASH, potentially improving liver health and overall quality of life.
How similar studies have performed: Previous research has shown promising results in understanding liver diseases through similar cellular and molecular approaches, indicating potential for success in this area.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Hirsova, Petra — Mayo Clinic Rochester
- Study coordinator: Hirsova, Petra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.