Understanding the causes of myxomatous valve disease
Mechanisms underlying myxomatous valve disease
This study is looking into the causes of mitral valve prolapse, a heart condition that many older adults have, to find new ways to treat it without surgery, using zebrafish and mice to help uncover important genetic and molecular clues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10837787 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind myxomatous degeneration, which leads to mitral valve prolapse, a condition affecting a significant portion of the population, especially the elderly. The study aims to explore the genetic and molecular factors involved in this disease using zebrafish and mice models. By understanding these mechanisms, the research seeks to pave the way for new non-invasive treatments that could prevent or improve mitral valve diseases, moving beyond current surgical options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with mitral valve prolapse or those at risk due to genetic factors, particularly older adults.
Not a fit: Patients with non-genetic causes of mitral valve disease or those who are not affected by valve conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of innovative treatments for mitral valve diseases, reducing the need for invasive surgeries.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to heart defects, suggesting potential for success in this area as well.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Waxman, Joshua — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Waxman, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.