Understanding the causes of muscle loss in older adults
Official title: Determinants and Outcomes of Age-related Muscle Loss
Funded at Hebrew Rehabilitation Center for Aged · NIH-10877900 · Data updated 2026-11-12
This study is looking at what causes muscle loss in older adults and how it can lead to falls and injuries, using a simple urine test to measure muscle mass while considering both genetics and lifestyle choices.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hebrew Rehabilitation Center for Aged NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 30, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $758,379 |
| NIH project number | 5R01AG065265-04 |
| Project ID | NIH-10877900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who may be experiencing muscle loss or are at risk for falls and fractures.
✕Less likely to help
Patients who are not older adults or those without concerns related to muscle mass loss may not benefit from this research.
What this research studies
This research investigates the factors that contribute to muscle loss in older adults and its associated risks, such as falls and fractures. By using a precise method called D3-creatine dilution, the study aims to measure total muscle mass from a simple urine sample. It will explore both genetic and lifestyle factors that influence muscle mass and how these factors may lead to increased risks of injuries. The research involves analyzing data from two large community-based groups of older adults to draw meaningful conclusions.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for muscle loss, ultimately reducing the risk of falls and fractures in older adults.
How similar studies have gone: Previous research has shown promising results in understanding muscle loss and its implications, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Hebrew Rehabilitation Center for Aged
Boston, United States Active
Researchers
- Principal investigator: Kiel, Douglas P. — Hebrew Rehabilitation Center for Aged
- Study coordinator: Kiel, Douglas P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.