Understanding the causes of mobility issues in Alzheimer's disease and related disorders
Elucidating the molecular drivers of impaired mobility within and outside the CNS in Alzheimer’s disease and related disorders
This study is looking at how certain changes in the brain, spinal cord, and muscles might affect movement in older adults, especially those with Alzheimer's and similar conditions, to help us understand what makes it harder for them to get around.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10613427 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that contribute to mobility impairments in older adults, particularly those with Alzheimer's disease and related conditions. By examining tissues from the brain, spinal cord, and muscles of deceased participants, the study aims to identify genetic and protein factors that influence mobility. The research utilizes a systems biology approach, integrating clinical data and postmortem samples to uncover drivers of mobility that may not be linked to observable pathologies. This comprehensive analysis seeks to provide insights into how various bodily systems interact to affect movement in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those diagnosed with Alzheimer's disease or experiencing mobility issues.
Not a fit: Patients who are younger than 21 years old or do not have mobility impairments related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving mobility and quality of life for patients with Alzheimer's disease and related disorders.
How similar studies have performed: Other research has shown promise in understanding mobility issues in aging populations, but this specific approach focusing on molecular drivers is relatively novel.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Buchman, Aron S — Rush University Medical Center
- Study coordinator: Buchman, Aron S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.