Understanding the causes of liver cancer in Non-Hispanic Black Americans
Genomic and environmental drivers of HCC in Non-Hispanic Blacks: Nature and nurture
This study is looking at why liver cancer is more common and often more severe in Non-Hispanic Black Americans, focusing on how both genetics and environmental factors play a role, with the goal of finding better ways to prevent and treat this disease for those at higher risk.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10933003 on NIH RePORTER |
What this research studies
This research investigates the genetic and environmental factors contributing to the higher rates of hepatocellular carcinoma (HCC) in Non-Hispanic Black Americans. It aims to uncover how exposure to environmental pollutants and genetic predispositions lead to more aggressive forms of liver cancer in this population. By collaborating with experts in liver disease, the project seeks to develop new prevention and treatment strategies tailored to the unique presentation of HCC in these patients. The study will also create a polygenic risk score to help identify individuals at higher risk for cirrhosis and liver cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include Non-Hispanic Black individuals at risk for or diagnosed with liver cancer or cirrhosis.
Not a fit: Patients who are not of Non-Hispanic Black descent or those without liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for liver cancer specifically tailored to Non-Hispanic Black Americans.
How similar studies have performed: Previous research has shown success in understanding cancer disparities among different populations, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Branch, Andrea D. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Branch, Andrea D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.