Understanding the causes of left ventricular noncompaction cardiomyopathy
Official title: Novel pathogenesis of LVNC
Funded at Research Inst Nationwide Children's Hosp · NIH-11166859 · Data updated 2026-11-12
This study is looking into a rare heart condition called left ventricular noncompaction cardiomyopathy (LVNC) to understand how certain heart cells affect its development, which could help improve how we diagnose and treat this condition for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | May 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $683,048 |
| NIH project number | 1R01HL179812-01 |
| Project ID | NIH-11166859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with left ventricular noncompaction cardiomyopathy or those with a family history of the condition.
✕Less likely to help
Patients with other forms of cardiomyopathy unrelated to left ventricular noncompaction may not benefit from this research.
What this research studies
This research investigates left ventricular noncompaction cardiomyopathy (LVNC), a rare heart condition that arises during early heart development. The study aims to uncover the cellular and molecular mechanisms behind LVNC, focusing on the role of specific cell types, including cardiac endothelial cells, in heart formation. By utilizing advanced imaging technology and genetic models, the research seeks to identify how disruptions in these cells contribute to the development of LVNC. Patients may benefit from insights that could lead to improved diagnosis and treatment options for this condition.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of left ventricular noncompaction cardiomyopathy, potentially improving patient outcomes.
How similar studies have gone: While there has been research on cardiomyopathies, this specific investigation into the role of endothelial cells in LVNC is relatively novel and untested.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Li, Deqiang — Research Inst Nationwide Children's Hosp
- Study coordinator: Li, Deqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.