Understanding the causes of late-onset retinal and macular degeneration
Molecular mechanism underlying late-onset retinal/macular degeneration
This study is looking into the genetic changes that cause late-onset retinal and macular degeneration, which can affect your vision, and it hopes to find new ways to treat or prevent this condition by using mouse models that mimic what happens in humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10673053 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind late-onset retinal and macular degeneration, a condition that can lead to vision loss. It focuses on identifying genetic mutations and their effects on the eye's structure and function, particularly how they relate to the extracellular matrix and its role in eye health. By using mouse models that replicate human disease features, the research aims to uncover the underlying biological processes that contribute to this condition. Patients may benefit from insights that could lead to new treatments or preventive strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of late-onset retinal or macular degeneration, particularly those with a family history of the condition.
Not a fit: Patients with other forms of retinal degeneration unrelated to the genetic factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for late-onset retinal and macular degeneration, ultimately preserving vision for affected individuals.
How similar studies have performed: Previous research has shown success in understanding other forms of macular degeneration, suggesting that this approach may yield valuable insights as well.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ayyagari, Radha — University of California, San Diego
- Study coordinator: Ayyagari, Radha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.