Understanding the causes of heart disease in people with type 1 diabetes
Molecular Drivers of Atherosclerosis in Diabetes
This study is looking at how type 1 diabetes affects heart health differently than type 2 diabetes and people without diabetes, and it aims to find out what makes those risks unique so we can better understand and help those with type 1 diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11073485 on NIH RePORTER |
What this research studies
This research investigates the unique cardiovascular risks faced by individuals with type 1 diabetes compared to those with type 2 diabetes and non-diabetic individuals. It aims to uncover the molecular and cellular mechanisms that contribute to increased heart disease risk in type 1 diabetes, focusing on immune profiles and the characteristics of atherosclerotic plaques. By analyzing serum proteins and immune cell characteristics, the study seeks to identify distinct genetic and molecular drivers of atherosclerosis in diabetic patients. This comprehensive approach leverages advanced technologies and a collaborative team of experts in diabetes and cardiovascular disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are at risk for cardiovascular complications.
Not a fit: Patients with type 2 diabetes or those without diabetes may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for cardiovascular disease in patients with type 1 diabetes.
How similar studies have performed: Other research has shown promising results in understanding cardiovascular risks in diabetes, but this specific focus on type 1 diabetes is relatively novel.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Civelek, Mete — University of Virginia
- Study coordinator: Civelek, Mete
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.