Understanding the causes of genetic instability in blood disorders
Official title: Causes and consequences of genomic instability in myelodysplasia
Funded at Fred Hutchinson Cancer Center · NIH-10942010 · Data updated 2026-11-12
This study is looking at how certain genetic changes in blood stem cells can affect their ability to make healthy blood cells in people with myelodysplastic syndromes (MDS), with the hope of finding new ways to improve treatments for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $584,872 |
| NIH project number | 1R01CA292932-01 |
| Project ID | NIH-10942010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with myelodysplastic syndromes, particularly those with specific genetic mutations.
✕Less likely to help
Patients with myelodysplastic syndromes who do not have the identified genetic mutations may not benefit from this research.
What this research studies
This research investigates myelodysplastic syndromes (MDS), which are blood disorders that lead to anemia and other blood cell deficiencies. The study focuses on how genetic mutations in blood stem cells affect their ability to produce healthy blood cells. By examining the role of specific mutations and their impact on cellular structures, the research aims to uncover new therapeutic targets for MDS. Patients may benefit from insights that could lead to improved treatments or management strategies for this challenging condition.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for patients suffering from myelodysplastic syndromes.
How similar studies have gone: Previous research has shown promising results in understanding genetic mutations in blood disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Lee, Stanley Chun-Wei — Fred Hutchinson Cancer Center
- Study coordinator: Lee, Stanley Chun-Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.