Understanding the causes of general mental health issues in teenagers

Building a multi-factor etiological model of the emergence of general psychopathology (the "P factor") in adolescence with multi-modal neuroimaging in ABCD

NIH-funded research University of Michigan at Ann Arbor · NIH-11056043

This study is looking at how brain development during the teenage years can affect mental health for young people aged 12 to 20, and it aims to understand the different factors that play a role in this.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor NIH-funded
Lab location1 site (Ann Arbor, United States)
Project IDNIH-11056043 on NIH RePORTER

What this research studies

This research investigates the emergence of a general factor of psychopathology, known as the 'P factor', during adolescence by utilizing advanced neuroimaging techniques. It aims to identify the neurodevelopmental factors that contribute to this overarching mental health issue in youth aged 12-20. By analyzing data from the Adolescent Brain Cognitive Development (ABCD) study, which includes a large cohort of adolescents, the research will explore how changes in brain development affect mental health outcomes. The study will integrate various factors, including environmental, psychological, neural, and genetic influences, to build a comprehensive model of adolescent mental health.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescents aged 12-20 who may be experiencing or are at risk for mental health issues.

Not a fit: Patients outside the age range of 12-20 or those without any mental health concerns may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and treatment of mental health issues in adolescents.

How similar studies have performed: Previous research has shown promise in understanding psychopathology through similar neurodevelopmental approaches, indicating potential for success in this study.

Where this research is happening

Ann Arbor, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.