Understanding the causes of Frontotemporal Dementia linked to specific gene mutations
Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1
This study is looking into how certain gene changes related to Frontotemporal Dementia (FTD) affect brain cells, using models like fruit flies and mice, to help find new ways to understand and treat the disease for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10749900 on NIH RePORTER |
What this research studies
This research investigates the underlying mechanisms of Frontotemporal Dementia (FTD) caused by mutations in the CHMP2B and TBK1 genes. By utilizing various experimental models, including fruit flies, mice, and human cells, the study aims to explore how these genetic mutations affect cellular processes related to degradation pathways in the brain. Patients may benefit from insights gained into the disease's progression and potential new therapeutic targets. The research focuses on understanding both common and rare genetic mutations associated with FTD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Frontotemporal Dementia, particularly those with known mutations in the CHMP2B or TBK1 genes.
Not a fit: Patients with Frontotemporal Dementia not linked to the CHMP2B or TBK1 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from Frontotemporal Dementia and related conditions.
How similar studies have performed: Previous research has shown promise in understanding genetic contributions to neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Gao, Fen-Biao — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Gao, Fen-Biao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.