Understanding the causes of early gastric cancer development
Drivers of gastric pre-neoplasia
This study looks at how gastric cancer develops from early changes in the stomach lining, focusing on a specific gene called Kras, to help us understand what causes this cancer and find better ways to prevent and treat it for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10894082 on NIH RePORTER |
What this research studies
This research investigates the progression of gastric cancer from pre-cancerous conditions to cancerous states, focusing on the role of Kras activation in this process. By examining how Kras influences the transition from metaplasia to dysplasia and ultimately to adenocarcinoma, the study aims to identify key oncogenic drivers of gastric cancer. Patients may benefit from insights gained into the mechanisms of gastric cancer development, which could lead to improved prevention and treatment strategies. The research employs a combination of cellular and molecular biology techniques to explore these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of gastric conditions or those at high risk for gastric cancer.
Not a fit: Patients with no history of gastric issues or those who do not have risk factors for gastric cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and targeted therapies for gastric cancer.
How similar studies have performed: Previous research has shown that targeting oncogenic drivers like Kras can be effective in other types of cancers, suggesting potential for success in this area as well.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Choi, Eunyoung — Vanderbilt University Medical Center
- Study coordinator: Choi, Eunyoung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.