Understanding the causes of Diffuse and Intestinal Gastric Cancer
Initiation of Diffuse and Intestinal Non-Cardia Gastric Cancer
This study is looking into how two types of stomach cancer develop by examining the role of genes and infections, and it’s designed to help researchers find better ways to prevent and treat these cancers for people affected by them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11114610 on NIH RePORTER |
What this research studies
This research investigates the origins and progression of two main types of gastric cancer: Diffuse Gastric Cancer (DGC) and Intestinal Gastric Cancer (IGC). It aims to explore how genetic factors, such as the inactivation of specific tumor suppressor genes, and environmental influences, like Helicobacter infection, contribute to the development of these cancers. By using advanced mouse models and cutting-edge technologies, the study will analyze individual cells to identify their roles in cancer progression and map their characteristics. This comprehensive approach seeks to provide insights into the cellular origins of gastric cancer, which could lead to improved prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for gastric cancer, particularly those with a family history or known genetic predispositions.
Not a fit: Patients with gastric cancer that is not related to the genetic or environmental factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for gastric cancer, improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in understanding gastric cancer through genetic and environmental interactions, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Ryeom, Sandra — Columbia University Health Sciences
- Study coordinator: Ryeom, Sandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.