Understanding the causes of Diffuse and Intestinal Gastric Cancer
Initiation of Diffuse and Intestinal Non-Cardia Gastric Cancer
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10909921
This study is looking into how certain genes and infections can lead to two types of stomach cancer, and it's using special mouse models to better understand how these factors work together, so we can learn more about what causes these cancers and how they develop.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10909921 on ClinicalTrials.gov |
What this research studies
This research investigates the origins and progression of two main types of gastric cancer: Diffuse Gastric Cancer (DGC) and Intestinal Gastric Cancer (IGC). It aims to explore how genetic factors, such as the inactivation of specific tumor suppressor genes, and environmental influences, like Helicobacter infection, contribute to these cancers. Using advanced mouse models, the study will analyze the interplay between these factors and utilize cutting-edge technologies to examine individual cells and their environments. This comprehensive approach seeks to identify the cellular origins and mechanisms driving gastric cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for gastric cancer, particularly those with a family history or known genetic predispositions.
Not a fit: Patients with gastric cancer that is not related to the genetic or environmental factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for gastric cancer, improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in understanding gastric cancer through genetic and environmental studies, indicating that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RYEOM, SANDRA — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: RYEOM, SANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.