Understanding the causes of developmental and epileptic encephalopathies
Official title: Dissecting the Developmental and Epileptic Components of Encephalopathy in DEE
Funded at Baylor College of Medicine · NIH-11051230 · Data updated 2026-11-12
This study is looking at how early seizures might affect learning and behavior in kids with certain brain conditions, and it aims to find new ways to help improve their overall development, not just stop the seizures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $409,586 |
| NIH project number | 5R01NS131399-03 |
| Project ID | NIH-11051230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with developmental and epileptic encephalopathies, particularly those experiencing early life seizures and associated neurobehavioral challenges.
✕Less likely to help
Patients without a diagnosis of developmental and epileptic encephalopathies or those who do not experience seizures may not benefit from this research.
What this research studies
This research investigates the complex relationship between early life seizures and intellectual disabilities in patients with developmental and epileptic encephalopathies (DEEs). It aims to identify how genetic or structural lesions and frequent seizures contribute to neurobehavioral issues such as sleep disturbances and communication difficulties. By utilizing advanced genetic sequencing and mouse models, the study seeks to uncover new therapeutic approaches that go beyond just controlling seizures, focusing on improving overall developmental outcomes. The research employs cutting-edge techniques like genome manipulation and calcium imaging to gain insights into the underlying mechanisms of these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new precision therapies that improve developmental outcomes for patients with DEEs.
How similar studies have gone: Previous research has shown promise in using genetic models to understand and treat similar neurodevelopmental disorders, indicating a potential for success in this approach.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Krishnan, Vaishnav — Baylor College of Medicine
- Study coordinator: Krishnan, Vaishnav
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.