Understanding the causes of dementia through brain autopsy analysis
Neuropathology Core
This study is looking at brain tissue from people who had dementia to help find better ways to diagnose the condition early and discover new treatments, so we can better understand how dementia affects the brain and improve care for those living with it.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10873198 on NIH RePORTER |
What this research studies
This research focuses on using brain autopsy to diagnose dementia-related diseases, which is crucial for developing effective biomarkers and understanding the cellular changes that lead to dementia. By analyzing postmortem brain tissue, the study aims to identify reliable features for early diagnosis and support the discovery of drugs that can modify the course of dementia. The research will also collect and distribute biospecimens for further studies and support investigations into unique cases of cognitive aging and various forms of dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dementia or those who have experienced significant cognitive decline.
Not a fit: Patients who are not diagnosed with dementia or do not have cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of dementia, as well as the development of new treatments.
How similar studies have performed: Previous research has shown that autopsy-based studies have been instrumental in understanding dementia, indicating a strong potential for success in this approach.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Flanagan, Margaret E — Northwestern University at Chicago
- Study coordinator: Flanagan, Margaret E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.