Understanding the causes of dementia related to Alzheimer's disease and Lewy body disorders
Official title: Core C: Resource Core
Funded at University of Pennsylvania · NIH-10935307 · Data updated 2026-11-12
This study is looking at the buildup of harmful proteins in the brain that are linked to diseases like Alzheimer's and aims to help scientists understand how these changes affect memory and thinking, using brain samples from patients after they pass away.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $445,427 |
| NIH project number | 1P01AG084497-01A1 |
| Project ID | NIH-10935307 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or Lewy body disorders, particularly those who may participate in post-mortem examinations.
✕Less likely to help
Patients with non-neurodegenerative conditions or those who do not have a diagnosis related to Alzheimer's or Lewy body disorders may not benefit from this research.
What this research studies
This research focuses on the accumulation of harmful protein deposits in the brain that are characteristic of neurodegenerative disorders like Alzheimer's disease and Lewy body disorders. It aims to provide essential resources and support for scientists studying these conditions, including access to brain tissues and biological samples. By examining these deposits and their effects on cognitive function, the research seeks to uncover the underlying mechanisms of dementia. Patients' post-mortem brain examinations will help classify the neuropathology and document any co-existing neurodegenerative diseases.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of dementia, potentially improving diagnosis and treatment options for patients.
How similar studies have gone: Previous research has shown success in understanding neurodegenerative diseases through the examination of protein deposits, indicating that this approach is grounded in established scientific methods.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Lee, Edward Byung-Ha — University of Pennsylvania
- Study coordinator: Lee, Edward Byung-Ha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.