Understanding the causes of cleft palate
Official title: Transcriptome and Network Analysis of Cleft Palate
Funded at Mayo Clinic Rochester · NIH-11005530 · Data updated 2026-11-12
This study is looking into how genes work together to cause cleft palate, a common birth defect, to help find better ways to diagnose and treat it for those who are affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 3, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $730,554 |
| NIH project number | 7R01DE029322-05 |
| Project ID | NIH-11005530 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cleft palate or those at risk of developing this condition.
✕Less likely to help
Patients with cleft palate who are already receiving optimal treatment may not see additional benefits from this research.
What this research studies
This research investigates the complex biological processes involved in the development of cleft palate, a common birth defect. By analyzing gene expression and biological networks, the study aims to uncover how various genes and signaling pathways interact during palatogenesis. This could lead to better diagnostic methods and treatment options for affected individuals. The research combines insights from both human and mouse studies to create a comprehensive understanding of the condition.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for individuals with cleft palate.
How similar studies have gone: Previous research has shown promise in understanding genetic factors related to cleft palate, but this approach aims to provide a more integrated view of the biological processes involved.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Jabs, Ethylin Wang — Mayo Clinic Rochester
- Study coordinator: Jabs, Ethylin Wang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.