Understanding the causes of classic Bartter syndrome
Exploring the pathogenesis of classic Bartter syndrome
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-10868652
This study is looking at how genetic changes in classic Bartter syndrome affect kidney development, especially in a part of the kidney that helps manage salt, to find better ways to treat or manage the condition for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10868652 on ClinicalTrials.gov |
What this research studies
This research investigates classic Bartter syndrome, a genetic condition affecting kidney function due to mutations that disrupt salt reabsorption. The study focuses on how these mutations lead to developmental defects in kidney structures, particularly in the thick ascending limb of Henle's loop. By examining cell proliferation and death in kidney cells, the research aims to uncover the mechanisms behind kidney tubule hypoplasia associated with this syndrome. Patients may benefit from insights that could lead to improved treatments or management strategies for Bartter syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with classic Bartter syndrome or those with related genetic mutations affecting kidney function.
Not a fit: Patients with other forms of kidney disease unrelated to Bartter syndrome may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new understanding and potential treatment options for patients with classic Bartter syndrome.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown success in understanding genetic kidney disorders, suggesting potential for impactful findings.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, CHIH-JEN — UNIVERSITY OF IOWA
- Study coordinator: CHENG, CHIH-JEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Barter's Disease, Bartter Disease, Bartter Syndrome, Bartter syndrome (BS)