Understanding the causes of chronic low back pain
Mechanistic underpinnings of chronic low back pain
This study is looking at the tissues from people with chronic low back pain who are having spine surgery to understand what might be causing their pain, with the goal of finding better treatments for those who suffer from it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-10930059 on NIH RePORTER |
What this research studies
This research investigates chronic low back pain (CLBP), a leading cause of disability, by analyzing nerve, joint, muscle, and fascia tissues from patients undergoing spine surgery. Using advanced RNA sequencing techniques, the study aims to uncover transcriptional changes in these tissues that may contribute to CLBP. By examining the cellular makeup and interactions within these tissues, researchers hope to identify specific mechanisms driving the pain. The findings could lead to more effective treatments for individuals suffering from CLBP.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic low back pain who are scheduled for spine surgery.
Not a fit: Patients without chronic low back pain or those not undergoing spine surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from chronic low back pain.
How similar studies have performed: Previous research has shown promise in using RNA sequencing to understand pain mechanisms, suggesting potential for success in this approach.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Curatolo, Michele — University of Texas Dallas
- Study coordinator: Curatolo, Michele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.