Understanding the causes of brain network problems in Alzheimer's disease
Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease
This study is looking at how certain proteins in the brain might cause problems in people with Alzheimer's disease, and it's using special mouse models to help find new ways to treat the condition, which could lead to better care for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10897911 on NIH RePORTER |
What this research studies
This research investigates the complex factors that lead to brain network dysfunction in Alzheimer's disease (AD), which may contribute to cognitive decline. By utilizing advanced techniques in neurophysiology, behavior, and biology, the project aims to uncover how interactions between specific proteins, such as apolipoprotein E4 and amyloid-beta, affect brain function. The research involves studying novel mouse models to gain insights that could inform new therapeutic strategies for AD. Patients may benefit from improved understanding and potential treatments derived from these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those with the APOE e4 genotype.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better therapeutic strategies for Alzheimer's disease, potentially improving cognitive function and quality of life for patients.
How similar studies have performed: Previous research has shown promise in understanding the role of neural network dysfunction in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Mucke, Lennart — J. David Gladstone Institutes
- Study coordinator: Mucke, Lennart
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.