Understanding the causes of brain changes in Parkinson's disease
Determinants of Basal Ganglia Pathology in Parkinson's Disease
This study is looking at how nerve cells that produce dopamine break down in Parkinson's disease using a special mouse model, and it hopes to find new ways to improve treatments for people living with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11109620 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the degeneration of dopamine neurons in Parkinson's disease (PD) using a newly developed mouse model that mimics human disease progression. By studying this model, researchers aim to uncover how the loss of these neurons affects brain networks and leads to motor symptoms. The approach involves advanced techniques to analyze neuronal behavior and pathology, providing insights into the disease's progression and potential therapeutic targets. Patients may benefit from the findings that could lead to improved treatments for PD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk of developing it.
Not a fit: Patients with Parkinson's disease who are not responsive to dopamine treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with Parkinson's disease.
How similar studies have performed: Other research has shown success in using animal models to study Parkinson's disease, making this approach promising.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Surmeier, Dalton James — Northwestern University at Chicago
- Study coordinator: Surmeier, Dalton James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.