Understanding the causes of atrial fibrillation to improve treatment outcomes
Official title: Molecular Mechanisms of Atrial Fibrillation: A Multimodal Analysis
Funded at University of Arizona · NIH-11197308 · Data updated 2026-11-12
This study is looking at how atrial fibrillation (AF) works in the heart, especially in older adults, to find out which patients might do best with a treatment called ablation, so we can help them feel better sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $500,891 |
| NIH project number | 7R01HL170520-02 |
| Project ID | NIH-11197308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with atrial fibrillation, particularly those who may be considering or have undergone ablation therapy.
✕Less likely to help
Patients with atrial fibrillation who are not candidates for ablation therapy or those with other significant comorbidities may not benefit from this research.
What this research studies
This research investigates the underlying molecular mechanisms of atrial fibrillation (AF), a common heart rhythm disorder, particularly in older adults. By analyzing intracardiac electrograms and other data, the study aims to identify factors that predict the success of ablation therapy, which is a procedure used to treat AF. The goal is to develop models that can help select patients who are most likely to benefit from early intervention, thereby improving treatment outcomes and reducing the burden of AF. This collaborative effort combines various methodologies to enhance our understanding of AF and its management.
Why it matters
Potential benefit: If successful, this research could lead to better patient selection for ablation therapy, improving outcomes and reducing recurrence rates of atrial fibrillation.
How similar studies have gone: Previous research has shown that identifying predictors of successful ablation can improve patient outcomes, suggesting that this approach has potential for significant advancements.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Chiamvimonvat, Nipavan — University of Arizona
- Study coordinator: Chiamvimonvat, Nipavan
Related research
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A new tool uses patient data and heart MRI markers to identify heart failure patients without atrial fibrillation who might benefit from anticoagulation while minimizing bleeding risk.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.