Understanding the causes of atrial fibrillation in older adults
Exploring the Molecular Physiology of Atrial Fibrillation
This study is looking into how certain proteins in heart cells affect atrial fibrillation, especially in people over 65, to help find new ways to treat or prevent this heart rhythm issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11004366 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind atrial fibrillation (AF), a common heart rhythm disorder, particularly in individuals aged 65 and older. The study focuses on how certain proteins and channels in heart cells contribute to AF and explores innovative techniques to analyze these processes at a molecular level. By using advanced mouse models and structural studies, the research aims to uncover the role of calcium channels and adrenergic regulation in heart function and arrhythmias. Patients may benefit from insights that could lead to new treatments or prevention strategies for AF.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who may be experiencing or at risk for atrial fibrillation.
Not a fit: Patients under the age of 65 or those without any history of atrial fibrillation may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for atrial fibrillation, potentially reducing the risk of complications in older patients.
How similar studies have performed: Previous research has shown promising results in understanding atrial fibrillation through similar molecular and structural approaches, indicating a potential for significant advancements in treatment.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Marx, Steven O — Columbia University Health Sciences
- Study coordinator: Marx, Steven O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.