Understanding the causes of atrial fibrillation
The molecular determinants of atrial fibrillation
This study is looking into the genetic reasons behind atrial fibrillation (AF), a common heart rhythm issue, to help find better treatments for people with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11062449 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind atrial fibrillation (AF), a common heart rhythm disorder. By utilizing advanced techniques like multiomics, which combines RNA and chromatin accessibility sequencing, the study aims to identify genetic factors and pathways that contribute to AF. The goal is to uncover how specific genes, such as TBX5 and LKB1, influence heart cell function and arrhythmia development, ultimately leading to improved treatment strategies for patients. Participants may contribute to a deeper understanding of AF and its genetic underpinnings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with atrial fibrillation, particularly those over the age of 55.
Not a fit: Patients with arrhythmias unrelated to atrial fibrillation or those without a genetic predisposition to AF may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for atrial fibrillation, improving heart health and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to atrial fibrillation, indicating that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sweat, Mason Eric — Boston Children's Hospital
- Study coordinator: Sweat, Mason Eric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.