Understanding the causes of Alzheimer's disease
Elucidating the causal associations underlying Alzheimer's disease
This study is looking into what lifestyle changes might help reduce the risk of Alzheimer's disease by exploring how different traits and genetics are linked to the condition, so we can better understand how to prevent it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11023096 on NIH RePORTER |
What this research studies
This research investigates the underlying causes of Alzheimer's disease (AD) by identifying modifiable risk factors that could lead to lifestyle interventions. Using advanced genetic analysis techniques, the study aims to demonstrate causal relationships between various traits and AD outcomes. By employing methods like polygenic risk scoring and Mendelian randomization, researchers will analyze genetic data to uncover new risk factors for Alzheimer's that have not been previously identified. This approach seeks to enhance our understanding of how different factors contribute to the development of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are at risk for Alzheimer's disease due to genetic or lifestyle factors.
Not a fit: Patients who are already diagnosed with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective lifestyle interventions that reduce the risk of developing Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in identifying genetic risk factors for Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Andrews, Shea J — University of California, San Francisco
- Study coordinator: Andrews, Shea J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.