Understanding the causes of Adult T-cell leukemia/lymphoma
Official title: Pathophysiology of Adult T-cell leukemia/lymphoma
Funded at Rlr VA Medical Center · NIH-11098413 · Data updated 2026-11-12
This study is looking at Adult T-cell leukemia/lymphoma, a tough cancer that often hits young adults, especially veterans, to find out why some patients don’t respond well to treatment and how we can make those treatments better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rlr VA Medical Center NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX001799-13 |
| Project ID | NIH-11098413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with T-cell acute lymphoblastic leukemia, particularly those who have experienced treatment resistance.
✕Less likely to help
Patients with other types of leukemia or those who do not have T-cell acute lymphoblastic leukemia may not benefit from this research.
What this research studies
This research investigates Adult T-cell leukemia/lymphoma (T-ALL), a severe form of cancer that often affects young adults, particularly veterans. The focus is on understanding the underlying mechanisms that lead to treatment resistance and relapse in patients. By studying specific cancer cells that survive chemotherapy, the research aims to identify new therapeutic targets to improve treatment outcomes. The approach includes biochemical characterization of key oncogenes involved in the disease.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Adult T-cell leukemia/lymphoma, potentially improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting similar oncogenes in other aggressive leukemias, suggesting that this approach may be effective.
Where this research is happening
-
Rlr VA Medical Center
Indianapolis, United States Active
Researchers
- Principal investigator: Dave, Utpal P — Rlr VA Medical Center
- Study coordinator: Dave, Utpal P
Related research
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Targeting T-cell Signals for Adult T-cell Leukemia Lymphoma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.