Understanding the causes of a specific type of dementia in older adults
Official title: Molecular and cellular underpinnings of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC)
Funded at Brigham and Women's Hospital · NIH-10907813 · Data updated 2026-11-12
This study is looking into a type of brain change that can cause dementia in older adults, aiming to find out what happens at the molecular level so we can better diagnose and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,228,351 |
| NIH project number | 5R01AG080667-02 |
| Project ID | NIH-10907813 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 80 and over who are experiencing symptoms of dementia.
✕Less likely to help
Patients with forms of dementia unrelated to TDP-43 pathology may not benefit from this research.
What this research studies
This research investigates limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC), a significant cause of dementia in older adults. The study aims to uncover the molecular and cellular changes associated with LATE-NC, which could help in developing models for diagnosis and treatment. By analyzing genetic and transcriptomic data, researchers hope to identify specific pathways and biomarkers related to this condition. This work is crucial for advancing our understanding of dementia and improving patient care.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment options for patients suffering from LATE-NC and related dementias.
How similar studies have gone: While LATE-NC is a relatively new area of study, similar research on other forms of dementia has shown promise in identifying molecular targets for treatment.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Yang, Hyun-Sik — Brigham and Women's Hospital
- Study coordinator: Yang, Hyun-Sik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.