Understanding the causes and progression of pulmonary arterial hypertension in at-risk individuals
Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals
This study is looking at pulmonary arterial hypertension (PAH) to understand why some people with certain genetic traits get the disease while others don’t, hoping to find clues that could help improve treatment and outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10915445 on NIH RePORTER |
What this research studies
This research investigates pulmonary arterial hypertension (PAH), a serious condition that leads to high mortality rates. The study aims to explore the relationships between molecular markers and the progression of PAH, as well as identify genetic factors that may contribute to resilience against the disease. By conducting longitudinal assessments and molecular profiling over time, the researchers hope to uncover why some individuals with genetic mutations develop PAH while others remain unaffected. This approach seeks to provide a deeper understanding of the disease and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with pulmonary arterial hypertension and those who carry specific genetic mutations associated with the disease.
Not a fit: Patients without pulmonary arterial hypertension or those who do not carry the relevant genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies and improved management strategies for patients with pulmonary arterial hypertension.
How similar studies have performed: While there have been studies on PAH, this research takes a novel approach by focusing on longitudinal molecular profiling, which has not been extensively explored in this context.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Brittain, Evan L — Vanderbilt University Medical Center
- Study coordinator: Brittain, Evan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.