Understanding the causes and outcomes of biliary atresia in infants
Official title: Biological Basis of Phenotypes and Clinical Outcomes in Biliary Atresia
Funded at Ut Southwestern Medical Center · NIH-10824147 · Data updated 2026-11-12
This study is looking into biliary atresia, a liver condition in babies, to understand how it affects their health and treatment, with the goal of finding better ways to help kids with this condition live healthier lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | April 10, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $483,857 |
| NIH project number | 7R01DK083781-14 |
| Project ID | NIH-10824147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants diagnosed with biliary atresia, particularly those experiencing varying degrees of disease progression.
✕Less likely to help
Patients with biliary atresia who are already at end-stage liver disease may not benefit from this research.
What this research studies
This research investigates biliary atresia, a serious liver condition affecting infants, by exploring the biological mechanisms that lead to different clinical outcomes. The team will analyze genetic and protein markers to identify factors that influence disease progression and response to treatment. By utilizing advanced computer modeling and high-throughput analytics, they aim to uncover new therapeutic targets and improve predictions for patient survival. This research could lead to more personalized treatment strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better survival rates for infants with biliary atresia.
How similar studies have gone: Previous research has shown promising results in identifying biomarkers and therapeutic targets for biliary atresia, suggesting that this approach has potential for success.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Bezerra, Jorge a. — Ut Southwestern Medical Center
- Study coordinator: Bezerra, Jorge a.
Related research
Other NIH-funded projects on the same topics.
-
Genetic factors in virus-related biliary atresia in children
A study to understand how viral infections may trigger biliary atresia in very young children and how genetics influence this process.
-
MMP7-Positive Liver Cells Driving Fibrosis in Biliary Atresia
This study explores a specific liver cell type marked by MMP7 to understand why scarring progresses in biliary atresia and how it might be slowed.
-
How genes may cause biliary atresia
This project looks at how changes in a gene called PKD1L1 might lead to biliary atresia in babies and to later bile-duct inflammation.
-
Bifidobacterium breve to support bile flow in infants with cholestasis and biliary atresia
A tiny study in babies with biliary atresia or related cholestasis tests a safe probiotic supplement (B. breve) to help bile flow after a surgical procedure.
-
Mechanisms of neutrophil NETs and their role in biliary fibrosis in biliary atresia
A study to understand how certain white blood cells and their networks contribute to scarring in the bile ducts of infants with biliary atresia.
-
Understanding how immune cells contribute to liver scarring in infants with biliary atresia
This research explores how certain immune cells called neutrophils cause liver scarring in babies born with biliary atresia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.