Understanding the causes and outcomes of biliary atresia in infants
Biological Basis of Phenotypes and Clinical Outcomes in Biliary Atresia
This study is looking into biliary atresia, a liver condition in babies, to understand how it affects their health and treatment, with the goal of finding better ways to help kids with this condition live healthier lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10824147 on NIH RePORTER |
What this research studies
This research investigates biliary atresia, a serious liver condition affecting infants, by exploring the biological mechanisms that lead to different clinical outcomes. The team will analyze genetic and protein markers to identify factors that influence disease progression and response to treatment. By utilizing advanced computer modeling and high-throughput analytics, they aim to uncover new therapeutic targets and improve predictions for patient survival. This research could lead to more personalized treatment strategies for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants diagnosed with biliary atresia, particularly those experiencing varying degrees of disease progression.
Not a fit: Patients with biliary atresia who are already at end-stage liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better survival rates for infants with biliary atresia.
How similar studies have performed: Previous research has shown promising results in identifying biomarkers and therapeutic targets for biliary atresia, suggesting that this approach has potential for success.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Bezerra, Jorge a. — Ut Southwestern Medical Center
- Study coordinator: Bezerra, Jorge a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.