Understanding the causes and outcomes of acute interstitial nephritis
Defining the Pathogenesis and Prognosis of Human Acute Interstitial Nephritis
This study is looking at how the immune system affects kidney damage in people with acute interstitial nephritis, with the hope of finding better and safer treatments to help protect your kidneys and improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10866427 on NIH RePORTER |
What this research studies
This research investigates acute interstitial nephritis (AIN), a condition that can lead to acute kidney injury and chronic kidney disease. It focuses on understanding the immune responses that contribute to kidney damage in AIN, particularly the role of specific immune cells and cytokines. By analyzing kidney biopsies and urine samples, the study aims to identify potential new therapies that could be more effective and less toxic than current treatments. The goal is to improve patient outcomes by preventing the progression of kidney damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute interstitial nephritis, particularly those experiencing acute kidney injury.
Not a fit: Patients with acute interstitial nephritis caused by non-immune factors or those who do not have kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for acute interstitial nephritis, reducing the risk of chronic kidney disease.
How similar studies have performed: Previous research has shown promise in understanding immune mechanisms in kidney diseases, suggesting that targeted therapies could be effective, although this specific approach is still being explored.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Cantley, Lloyd G — Yale University
- Study coordinator: Cantley, Lloyd G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.