Understanding the causes and effects of small blood vessel disease in the brain
Official title: Mechanistic and Functional Evaluation of a Model of Cerebral Small Vessel Disease
Funded at University of California, San Francisco · NIH-11024293 · Data updated 2026-11-12
This study is looking at how small blood vessel problems in the brain can affect thinking and memory, especially in people with certain genetic traits, using a mouse model to help find new ways to manage or prevent dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $770,502 |
| NIH project number | 1R01NS140370-01 |
| Project ID | NIH-11024293 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cognitive impairment or dementia, particularly those with genetic mutations affecting cerebrovascular health.
✕Less likely to help
Patients without cognitive impairment or those not affected by small vessel disease may not benefit from this research.
What this research studies
This research investigates how small blood vessel disease in the brain contributes to cognitive impairment and dementia, particularly in individuals with specific genetic mutations. By studying a mouse model that mimics human conditions, researchers aim to uncover the underlying mechanisms of this disease and its progression. The study focuses on the role of genetic factors and signaling pathways that may influence cerebrovascular health and cognitive function. Patients may benefit from insights that could lead to new therapeutic approaches for managing or preventing dementia related to small vessel disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive health and quality of life for patients with dementia related to small blood vessel disease.
How similar studies have gone: Previous research has shown promising results in understanding cerebrovascular contributions to cognitive decline, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Gould, Douglas — University of California, San Francisco
- Study coordinator: Gould, Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.