Understanding the causes and effects of Primary Sclerosing Cholangitis using environmental and genetic data
Dissecting the pathogenesis and outcomes of PSC using multi-omics by studying the exposome and genome
This study is looking at how both your genes and your everyday environment, like what you eat and what you're exposed to, might play a role in the liver disease Primary Sclerosing Cholangitis (PSC), with the goal of finding better ways to manage and treat it for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10453649 on NIH RePORTER |
What this research studies
This research investigates Primary Sclerosing Cholangitis (PSC), a serious liver disease, by analyzing both genetic and environmental factors that may contribute to its development. The study aims to create a comprehensive resource that combines data on lifestyle, diet, and exposures to toxins with genetic information. By collaborating with experts from multiple institutions, the research will utilize advanced techniques to uncover how these factors interact and influence the progression of PSC. Patients may benefit from insights that could lead to better management and treatment options for this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Primary Sclerosing Cholangitis or those at risk due to related conditions like inflammatory bowel disease.
Not a fit: Patients with liver diseases unrelated to PSC or those who do not have any genetic or environmental risk factors for PSC may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new therapies for patients suffering from PSC.
How similar studies have performed: Previous research has shown promise in understanding complex diseases through multi-omics approaches, suggesting that this study could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lazaridis, Konstantinos N — Mayo Clinic Rochester
- Study coordinator: Lazaridis, Konstantinos N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.