Understanding the causes and effects of fragile X-associated ovarian insufficiency
FXPOI: Mechanisms and Modifiers
This study is looking at how certain genes affect early menopause and related health issues in women with a fragile X gene change, with the goal of finding ways to help improve their health and fertility.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10907685 on NIH RePORTER |
What this research studies
This research investigates the mechanisms and modifiers of fragile X-associated primary ovarian insufficiency (FXPOI) in women who carry a fragile X premutation allele. It aims to understand how these genetic factors contribute to early cessation of menstruation and associated health risks, such as reduced fertility and low bone density. By studying the molecular pathways involved, the research seeks to identify potential interventions that could improve health outcomes for affected women. The approach includes analyzing genetic data and biological samples to uncover the underlying mechanisms of FXPOI.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who carry a fragile X premutation allele and are experiencing or at risk for FXPOI.
Not a fit: Patients who do not carry a fragile X premutation allele or who are not affected by FXPOI may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for women at risk of FXPOI and related health issues.
How similar studies have performed: Previous research has shown promising results in understanding the genetic mechanisms of fragile X syndrome, suggesting that this approach may yield valuable insights into FXPOI as well.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Allen, Emily Graves — Baylor College of Medicine
- Study coordinator: Allen, Emily Graves
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.