Understanding the brain's structure in Alzheimer's disease
Official title: Architecture of Alzheimer's Disease
Funded at University of California at Davis · NIH-10885298 · Data updated 2026-11-12
This study is looking at how brain cells, especially neurons and astrocytes, work together in people with Alzheimer's disease to see how their communication affects memory and learning, with the hope of finding new ways to help treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $467,593 |
| NIH project number | 1R21AG083965-01A1 |
| Project ID | NIH-10885298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates the complex interactions between different cell types in the brain, particularly focusing on neurons and astrocytes, to understand their roles in Alzheimer's disease. By using advanced imaging techniques and mass spectrometry, the study aims to explore how these cells communicate and how their molecular states can affect cognitive functions like memory and learning. The goal is to identify the unique characteristics of brain cells in Alzheimer's patients compared to healthy individuals, which could lead to better treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding brain cell interactions in other neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Neumann, Elizabeth Kathleen — University of California at Davis
- Study coordinator: Neumann, Elizabeth Kathleen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.