Understanding the brain's blood vessels and their role in Alzheimer's disease
Evaluation of the neurovascular unit in the setting of pathogenesis and treatment of autosomal dominant Alzheimer disease
This study is looking at how the connections between blood vessels and brain cells affect Alzheimer's disease, with the hope of finding new ways to treat it, especially for older adults.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11053484 on NIH RePORTER |
What this research studies
This research investigates how the neurovascular unit, which includes blood vessels and brain cells, contributes to the development and treatment of Alzheimer's disease. By using advanced imaging techniques and molecular analysis, the research aims to uncover the complex interactions between amyloid-beta accumulation and vascular changes in the brain. Patients may benefit from insights that could lead to new therapeutic strategies targeting both amyloid-beta and vascular health in Alzheimer's. The study focuses on understanding how age-related factors influence these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those with a familial history of the condition.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain health and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of vascular factors in Alzheimer's disease, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Joseph-Mathurin, Nelly Cecile — Washington University
- Study coordinator: Joseph-Mathurin, Nelly Cecile
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.