Understanding the brain mechanisms behind traumatic dissociation in individuals with PTSD

Multimodal Approaches to Neurobiology of Traumatic Dissociation

NIH-funded research Mclean Hospital · NIH-10769728

This study is looking at how feelings of disconnection and memory loss after trauma affect people with PTSD, and it aims to find new ways to help those struggling with these symptoms during treatment.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMclean Hospital NIH-funded
Lab location1 site (Belmont, United States)
Project IDNIH-10769728 on NIH RePORTER

What this research studies

This research investigates how traumatic dissociation, which includes symptoms like depersonalization and amnesia, affects individuals who have experienced trauma, particularly in relation to PTSD treatment. The study aims to explore the biological mechanisms underlying these dissociative symptoms and how they interact with treatment outcomes. By examining both neural and digital markers of dissociation, the research seeks to identify potential new interventions for those suffering from these debilitating symptoms. Patients may be monitored through various assessments to better understand their experiences and responses to treatment.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 who have experienced trauma and exhibit dissociative symptoms related to PTSD.

Not a fit: Patients who do not have a history of trauma or do not exhibit dissociative symptoms may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective treatments for individuals experiencing traumatic dissociation and improve their overall mental health outcomes.

How similar studies have performed: While there has been limited research specifically targeting the neurobiology of traumatic dissociation, similar studies in PTSD have shown promise in understanding the biological underpinnings of mental health disorders.

Where this research is happening

Belmont, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Mental health disordersPsychiatric Disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.