Understanding the brain mechanisms behind loneliness

A hierarchical examination of the neural and computational mechanisms underlying loneliness

NIH-funded research Icahn School of Medicine at Mount Sinai · NIH-10923384

This study is looking at how our brains and thinking affect feelings of loneliness and social isolation, with the hope of finding new ways to help people feel more connected and less lonely.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionIcahn School of Medicine at Mount Sinai NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-10923384 on NIH RePORTER

What this research studies

This research investigates the neural and cognitive processes that contribute to feelings of loneliness and social isolation. By examining how individuals perceive, learn, and make decisions about social interactions, the study aims to uncover the underlying mechanisms that lead to loneliness. The research will utilize advanced computational models to analyze social information processing and its impact on mental health. Ultimately, the goal is to inform new strategies for improving social connections and reducing loneliness in the population.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 who experience feelings of loneliness or social isolation.

Not a fit: Patients who do not experience loneliness or have no interest in improving their social connections may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to innovative interventions that enhance social connections and reduce loneliness, improving overall mental health.

How similar studies have performed: Previous research has indicated that understanding the cognitive and neural basis of social behaviors can lead to effective interventions, suggesting potential success for this approach.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.